Postdoctoral Fellowships in the Neurosciences
Top 16 Postdoc In Neuroscience profiles | LinkedIn
Postdoc In Neuroscience salary is full-time annual starting salary. Intern, contractor and hourly pay scale vary from regular exempt employee. Compensation depends on work experience, job location, bonus, benefits and other factors.
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The BRI's Arnold Scheibel Distinguished Postdoctoral Fellow in Neuroscience Lecture honors one postdoctoral fellow annually for outstanding research in neuroscience, comprises part of the Joint Seminars in Neuroscience series, and confers a prize to attend a scientific meeting.
The 2014 award winner, Jason Stein, PhD, is from the laboratory of Daniel Geschwind. He presents : Evaluating Human Neural Stem Cell Models using a Transcriptomic Rubric. Jason is introduced by Baljit Khakh, PhD, Professor of Physiology and Neurobiology at UCLA's David Geffen School of Medicine.
Abstract: Neural stem cells have been adopted to model a wide range of neuropsychiatric conditions in vitro. However, how well such models correspond to in vivo brain has not been evaluated in an unbiased, comprehensive manner. Our work using transcriptomic analyses has enabled comparison of in vitro systems to developing human fetal brain. Using our analysis methods, we observe strong conservation of in vivo gene expression and network architecture in differentiating primary human neural progenitor cells. Conserved modules are enriched in genes associated with autism, supporting the utility of these stem cells for studying neuropsychiatric disease. We also developed and validated a machine learning approach called CoNTExT that identifies the developmental maturity and regional identity of in vitro models. We observed strong differences between in vitro models, including hiPSC-derived neural progenitors from multiple laboratories. This work provides a systems biology framework for evaluating in vitro systems and supports their value in studying the molecular mechanisms of human neurodevelopmental disease.